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Acute neutropenia induced by antibiotics is a rare side effect of this frequently prescribed class of drugs
The pharmacokinetics of linezolid in patients with neutropenia did not differ from the overall compassionate-use population
Linezolid is an alternative to vancomycin for the long-term treatment of gram-positive bacterial orthopedic infections because of its antibacterial spectrum and oral bioavailability, but duration-related myelosuppression could offset its advantages
We retrieved two prospective comparative studies (one of them a double-blind, randomized, controlled trial), a prospective The available evidence suggests that linezolid may be successful in a significant proportion of neutropenic patients with infection, despite the fact that it is a bacteriostatic agent
Interestingly there is no literature in which both are compared in the setting of febrile neutropenia
Linezolid is an important therapeutic option for infections from multi-drug resistant Gram-positive pathogens
Here, we present a case of linezolid-induced severe neutropenia, which improved after switching to tedizolid
Linezolid is an oxazolidinone class antibiotic that is used for serious or problematic infections caused by resistant enterococcal or staphylococcal organisms
It works by stopping the growth of bacteria
The optimal antibiotic therapy for the treatment of HAP caused by Gram-positive organisms is controversial
V ancomycin • CID 2006:42 (1 March) • 601 T able 2
* In patients with MRSA colonization or an epidemiological situation of high endemicity, consider combination with linezolid or vancomycin
It is usually the consequence of a reduced number of circulating neutrophils, although a reduced number of lymphocytes, monocytes, eosinophils, or basophils may also contribute
7, 15, 16, 17, 25, 27 The 2010 IDSA guidelines for the use of antimicrobial agents in neutropenic patients with cancer recommend considering the initial use of linezolid or daptomycin for febrile neutropenic VRE Linezolid can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection
Perhaps the ability to switch from parenteral to oral linezolid might, in the end, cut the mustard, since patient could be discharged earlier
On POD 47, dose of clindamycin was increased
Linezolid and daptomycin are emerging alternatives to glycopeptides; however, more clinical experience is needed, especially in Neutropenia is defined as an abnormally low absolute neutrophil count (ANC) and can be further delineated as severe or profound (see below)
Neutropenia: Absolute neutrophil count (ANC) <500 cells/mm3 or <1000 cells/mm3 with a predicted decline to >1000 cells/mm3: start linezolid 600 mg every 12 hours PO/IV b
Suspicion of vancomycin-resistant enterococcus calls for the addition of linezolid or daptomycin Abstract
Its prescription is rampant and is going to increase exponentially due to the ubiquity of these organisms
Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events, such as anemia, thrombocytopenia, and neutropenia
In rats administered linezolid orally for 6 months, non-reversible, minimal to mild axonal degeneration of sciatic nerves Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events, such as anemia, thrombocytopenia, and neutropenia
Linezolid may be used for definite or suspected infection with vancomycin-resistant enterococci
Thrombocytopenia and a slight increased risk for anemia were evident at ≥2 weeks of linezolid treatment
We evaluated the results of linezolid therapy in neutropenic cancer patients
The pharmacokinetics of linezolid in patients with neutropenia did not differ from the overall compassionate-use population
pneumoniae, and other Enterobacterales (CRE) Chemotherapy-associated
Linezolid has been associated with reversible thrombocytopenia and anemia, predominately in patients with serious infections treated beyond the recommended 28
Linezolid was safe and effective in
3 C) or a temperature greater than or equal to 100
4 %
Interestingly there is no literature in which both are compared in the setting of febrile neutropenia
Linezolid is used to treat prosthetic joint infection after total hip arthroplasty
Resistance to linezolid can develop with prolonged treatment or if the dose is less than that recommended
In case of grade 3 anemia, consider Linezolid monitoring is necessary due to the high frequency of hematological toxicity in patients with DRF and the relationship between blood concentration and safety
Linezolid is an antibiotic used to treat certain serious bacterial infections
Por lo general, se toma con o sin alimentos dos veces al día (cada 12 horas) durante 10 a 28 días
The pharmacokinetics of linezolid in patients with neutropenia did not differ from the overall compassionate-use population
Non-FDA uses include anthrax, bone and joint infections, brain abscess, febrile neutropenia, infectious arthritis, meningitis, orthopedic device-related infection, osteomyelitis, sepsis, subdural empyema, and ventriculitis
However, risk factors for LZD-associated TP have been reported in Western patients with relatively heavy body weight
neutropenia, eosinophilia
* In patients with MRSA colonization or an epidemiological situation of high endemicity, consider combination with linezolid or vancomycin
It is usually the consequence of a reduced number of circulating neutrophils, although a reduced number of lymphocytes, monocytes, eosinophils, or basophils may also contribute
The importance of VRE colonization to guide the empiric use of antibiotics in febrile neutropenia remains a matter of debate